Call: Era-Net, JPI-HDHL-INTIMIC (2017): Interrelation of the Intestinal Microbiome, Diet and Health

Title: Long-term impact of gestational and early-life dietary habits on infant gut immunity and disease risk

Acronym: EarlyFOOD

Period: 2018-2022

Partners: Isabella ANNESSI-MAESANO (UPMC, France), Bart KEIJSER (TNO, The Netherlands), Marta SCHUHMACHER (URV, Spain) and Sandra BALDACCI (CNR, Italy) and Martin LARSEN (Coordinator, CIMI, France)

Abstract.

What: Man is colonized immediately upon birth by environmental microbes of primarily maternal origin. Initial colonization and transfer of maternal immunity through breastfeeding are believed to impact infant health at short- and long-term by conferring protection from infection and potentially resistance to metabolic and allergic diseases. The project proposes to assess the importance of dietary habits on maternal immunity (sIgA in gut microbiota and breast milk) and on neonatal colonization and installation of immunological tolerance by a novel high-throughput immune-metagenomic approach.

How: EarlyFOOD will integrate immuno-metagenomics, metabolomics and toxicological as well as epidemiological data, such as exposure to dietary-derived metabolites and pollutants as well as infectious events, antibiotics, allergens and air pollutants in a birth cohort of individuals living across Europe in environments of different biodiversity. The impact of gestational and early-life dietary habits on dysbiotic states of microbiota will be identified by biostatistical modelization of the risk of developing metabolic and allergic disease as well as neurobehavioral disorders. The program will identify predictive biomarkers and early-life preventive strategies for the growing epidemic of human metabolic and allergic diseases. Such advances may have important impact on public health and generate socio-economic benefits.

Who: The earlyFOOD consortium consists of five partners, coordinated by Martin Larsen, Centre d’immunologie et des maladies infectieuses (France); email contact: This email address is being protected from spambots. You need JavaScript enabled to view it.. The other consortium partners are Isabella Annesi-Maesano, UPMC (France), Bart Keijser, TNO (The Netherlands); Marta Schuhmacher, Universitat Rovira i Virgili (Spain) and Sandra Baldacci, CNR Institute of Clinical Physiology (Italy).

Articles and other output from this project: 

Partner CIMI: R. VILLETTE, WG 1: Intestinal Microbiome in early life, JPI Healthy Microbiome Symposium, Vienna, Austria, 2022

Articles citing the EarlyFOOD project: