Polyfunctional T cells correlate with immune protection in vitro and in vivo
T cell responses induced either naturally (infection) or artificially (vaccine) can vary in quality as measured by their functional capacity. A number of functional parameters have been studied in the past, such as cytokines, chemokines and degranulation molecules. It is believed that the capacity to perform multiple functions simultaneously at the single-cell level, hence T cell polyfunctionality, is correlated with T cell efficacy. I have recently introduced a novel mathematical algorithm, the polyfunctionality index, which quantifies polyfunctionality and allow a more thorough evaluation of the impact of polyfunctionality with regards to T cell efficacy.
The polyfunctionality index has been employed in a number of studies and on various cell subsets (T cells and Dendritic cells) demonstrating its broad scope and large potential.
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